I. Explanation of the change and continuous supervision of the host brokerage
Date of change: October 14, 2021;
The original sponsoring brokerage: Guotai Junan;
After the change, the main brokerage firm: Tianfeng Securities;
Starting from October 14, 2021, the company's continuous supervision and lead brokerage will be changed from Guotai Junan to Tianfeng Securities.
Guotai Junan, the original sponsor brokerage firm, has always followed the principle of diligence and due diligence since serving as the company's sponsor brokerage firm, conducted full investigation and prudent verification of the company's information disclosure, and performed its continuous supervision obligations diligently and conscientiously. In accordance with the agreement signed by both parties and the relevant business rules formulated by the China Securities Regulatory Commission and the National SME Share Transfer System Co., Ltd., Guotai Junan supervises and assists the company in timely compliance with the "Company Law of the People's Republic of China" and the "National SME Share Transfer System Business Rules" (Trial)" and other relevant regulations, handle information disclosure and other matters, and perform continuous supervision obligations to the company with due diligence and faithfulness.
In view of the company's strategic development needs, after full communication and friendly negotiation between the company and Guotai Junan, the two parties have decided to terminate the continuous supervision agreement and reach an agreement on the termination of the agreement and related matters.

2. The review of changes and continuous supervision of the host brokerage firm
This change of continued supervision of the sponsoring securities firm has been reviewed and approved at the 17th meeting of the company's second board of directors and the company's second extraordinary general meeting of shareholders in 2021.

3. Changes to the signing of the agreement to continuously supervise the host brokerage firm
In accordance with the relevant requirements and regulations of the China Securities Regulatory Commission and the National Small and Medium-sized Enterprise Share Transfer System Co., Ltd., on September 30, 2021, the company and Guotai Junan signed the "Continuing Supervision and Cancellation Agreement" with effective conditions, and on the same day with Tianfeng Securities The company limited by shares signed the "Continuing Supervision Agreement" with effective conditions.
The National SME Share Transfer System Co., Ltd. issued a letter of no objection on October 14, 2021. From October 14, 2021, the agreement of the parties will take effect, and Tianfeng Securities will continue to supervise the lead brokerage.
This change of the company's continued supervision of the lead brokerage will not cause any risk or impact on the company's production and operation activities.

Shanghai Yan'an Pharmaceutical Yangpu Co., Ltd.
Board of Directors
October 18, 2021